To investigate whether AMPK activation could influence serum lipid in a mouse model of atherosclerosis, apoE−/− mice fed a high-fat diet were treated with vehicle, A-769662 (30 mg/kg, ip), AICAR (200 mg/kg, ip), metformin (260 mg/kg, by gavage), or IMM-H007 (200 mg/kg, by gavage). The gene discussed is APOE; the disease is atherosclerosis.