BUD13 and metabolic syndrome: In order to understand the epistatic nature of these SNPs, we performed pair-wise interaction analyses for all the possible SNP pairs against dyslipidemia and quantitative lipid traits and found rs10488699-rs2187126 pair of the BUD13 gene to confer significant risk (Interaction odds ratio = 14.38, P = 7.17 × 105) towards dyslipidemia.