This study builds on previous in silico work [6,37,38] on investigating the substrate for AF in potassium channel-linked SQTS by utilising multi-scale idealised atrial tissue models as well as the 3D virtual human atrium, which incorporates heterogeneous atrial electrophysiology in an anatomically-realistic setting [23,34]. This evidence concerns the gene KCNA3 and atrial fibrillation.