In patients with ischemic heart disease, the amount of coronary calcium deposits has been reported to be inversely associated with the level of IGF-1 [9], and in several studies a low level of IGF-1 has been associated with increased risk of ischemic heart disease or myocardial infarction, as seen in both human and animal models [10–12]. The gene discussed is IGF1; the disease is coronary artery disorder.