AKT1 and central nervous system cancer: In our previous studies, we have observed that 20-Hydroxyeicosatetraenoic acid (20-HETE), an active product of arachidonic acid metabolism by cytochrome P450, can activate several intracellular protein kinases including extracellular signal–regulated kinases (ERK) 1/2, phosphatidylinositol-3-kinases (PI3K) and protein kinase B (AKT), and growth factors such as vascular endothelial growth factor (VEGF) or receptors such as epidermal growth factor receptor (EGFR) leading to increased proliferation and neovascularization in U251 glioma cells and MDA-BM-231 metastatic breast cancer cells [8–10].