CFLAR and urinary bladder carcinoma: Conticello et al. [28] reported that IL-4 stimulation resulted in up-regulation of anti-apoptotic protein as cFLIP/FLAME-1 and Bcl-xL, inhibiting apoptosis induced by CD95 (Fas/APO-1) and chemotherapeutic drug stimulation in primary prostate, breast, and bladder cancer.