IRF3 and nervous system disorder: Interestingly, while Lazear et al., reported severe neurological disease in Irf3−/−Irf5−/−Irf7−/− triple knock-out (TKO) and Ifnar1−/− mice following subcutaneous inoculation with either a contemporary human isolate from French Polynesia (H/PF/2013) or the original Ugandan ZIKV strain (MR766), they found no overt disease in Irf3−/−, Irf−/−, and Mavs−/− single knock-out mice [59].