Whether the increased SCN AVP-ir found in the female depression group also leads to a stimulating effect on the HPA activity and thus to more depressive symptoms should be a topic for further studies, since in our previous study (Zhou et al. 2001), we found decreased SCN AVP-mRNA in depression, which prompted our proposal of a reduced production and release of AVP from the SCN. This evidence concerns the gene AVP and depressive disorder.