HSPB8 and amyotrophic lateral sclerosis: Heat shock protein B8 (HSPB8) is a small heat shock protein (sHSP), which has been found mutated in specific forms of motor neurophaty (Ghaoui et al. 2016; Irobi et al. 2004; Tang et al. 2005), and it is highly expressed in anterior horn spinal cord motoneurons that survive in ALS mice at end stage of disease (Crippa et al. 2010a; Crippa et al. 2010b).