TP53 and neoplasm: The most notable properties of HIPK2 in tumors are that its inhibition or dysfunction leads to impairment of p53 function and the activation of oncogenic pathways that are important for tumor progression, angiogenesis, and resistance to chemotherapy or radiation therapy [17, 18], because HIPK2 is activated by several types of genotoxic damaging factors such as UV radiation, ionizing radiation, and antitumor drugs including cisplatin, adriamycin, and roscovitine [18–21].