Oral administration of EeSs boosted the expression of Sod1, Cat, Gpx-1, Hmox-1, and Nqo-1 mRNA levels in the diabetic mice liver (Figure 5(a)), suggesting that EeSs has a strong antioxidant potential to quince free radicals and hence the ability to prevent diabetes-associated complication. This evidence concerns the gene HMOX1 and diabetes mellitus.