Moreover, Gal-3 also diminished the ability of monocytes to differentiate into DCs in response to GM-CSF and the ability of monocyte-derived dendritic cells to stimulate proliferation of CD1b-restricted T cells in response to mycobacterial antigens, resulting in a deficient activation of the cell-mediated adaptive immune response which is necessary to control the infection [37]. The gene discussed is LGALS3; the disease is infection.