Thus, it was revealed that binding of Gal-3 (whose release is induced during infection by influenza A virus) to the surface of epithelial cells modulates the expression of RIG-1 and SOCS-1 and the activation of ERK, AKT, and JAK/STAT1 signaling pathways, resulting in a deregulated release of proinflammatory cytokines [77]. Here, LGALS3 is linked to infection.