Recent studies have demonstrated that increased expression of LAMP3 correlated with unfavorable prognosis of patients with esophageal squamous cell carcinoma [12], gastrointestinal stromal tumor (GIST) [13], breast cancers [14, 15], cervical cancer [16], and head and neck squamous cell carcinomas [17]. Here, LAMP3 is linked to esophageal squamous cell carcinoma.