MAVS and viral infectious disease: Compared to MAVS-ΔN141, these chimeric mutants MAVS-ΔN141-(Bcl-xL-TM) and MAVS-ΔN141-(VAMP-2-TM) lost their inhibitory effects on IFN production and MAVS aggregation upon virus infection (Supplementary Fig. 3a,b), though they contain active regions for interaction with downstream effectors.