TP53 and colonic neoplasm: Few studies showed the influence of p53 mutation on lipid profiles such as an observation in the change of unsaturated acyl chains of phospholipids (PLs) toward more saturated moieties in p53 knockout (KO) liver cells10, a decrease of acyl chain length of phosphatidylinositol (PI) by p53 mutation in pancreatic cancer11, and an increase of phosphatidylcholine (PC) levels in p53 KO colon cancer cell lines by magnetic resonance imaging (MRI) and spectroscopy (MRS)12.