TP53 and obesity due to melanocortin 4 receptor deficiency: Since p53 is associated with the maintenance of mitochondrial functional properties in the skeletal muscle15, 16 and dysfunctional utilisation of lipids in mitochondria is associated with muscle-related diseases such as diabetes, obesity, and sarcopenia17–20, it is important to investigate the role of p53 in lipid metabolism of skeletal muscles.