Nevertheless, considering the main role of NF-κB and Sox9 modulating HSC phenotype38, 39, and the findings described above, we herein suggest that in the specific scenario of CLD liraglutide may improve HSC phenotype and liver microcirculation through a GLP-1R independent mechanism, being the NF-κB–Sox9 pathway a solid candidate to mediate, at least in part, these effects. This evidence concerns the gene SOX9 and congenital secretory chloride diarrhea 1.