Indeed, previous studies demonstrated that IL-10 transgene or IL-10 knockout could significantly inhibit or increase the development of atherosclerosis2, 3, 9, we infer that a slight effect of IL-10R neutralizing antibodies on atherosclerosis in PBS group was caused by: 1) IL-10 knockout but not IL-10R antibodies could inhibit IL-10 pathway completely, 2) a significant increased IL-10 by both atherosclerotic inflammation and IL-37 but not atherosclerotic inflammation alone respond to IL-10R antibodies well. The gene discussed is IL37; the disease is atherosclerosis.