The results showed that the atherosclerosis lesion size in the aortic sinus of the IL-37 plus anti-IL-10R mAb group was significantly increased compared to that of the IL-37 plus isotype antibody group, however, anti-IL-10R mAb treatment did not increase the atherosclerosis lesion size in PBS group, suggesting that IL-10 is indispensable for the antiatherogenic effects of IL-37, which is consistent with our previous study10. The gene discussed is IL10; the disease is atherosclerosis.