The results showed that the atherosclerosis lesion size in the aortic sinus of the IL-37 group was significantly decreased compared to that of the control group (3.22 ± 0.16 × 105 μm2 versus 4.46 ± 0.17 × 105 μm2, P < 0.01; Fig. 2B). This evidence concerns the gene IL37 and atherosclerosis.