In addition, cases with tumor size T1 (p = 0.002), T3 (p = 0.003) and T4 (p = 0.002) also displayed increased level of circulating NRP-1 compared to T2 tumor size cases (F(3,48) = 6.592, p = 0.001) (Fig. 1d). Here, NRP1 is linked to neoplasm.