Similar to associations observed with tumor size, SNAI1 and SEMA4A expression in PBMCs was significantly downregulated in patients with Stage 2 (p = 0.014 & 0.025), Stage 3 (p = 0.020 & 0.013) and Stage 4 (p = 0.036 & 0.009) disease compared to Stage 1 patients as indicated by both multivariate (Fig. 4e and f) and univariate analysis (Table 2). The gene discussed is SNAI1; the disease is neoplasm.