After exclusion of EV derived from other cells rather than the syncytiotrophoblast, the results showed a significant reduction in PlAP and eNOS double-positive events per milliliter of plasma-derived STBMV from preeclampsia (12 798±7121) compared with NP (62 838±15 246; **P<0.01; Figure 2C). Here, ALPP is linked to preeclampsia.