Then, to determine whether CerS1/C18‐ceramide signaling plays any roles in cisplatin‐mediated growth inhibition in HPV(+) HNSCC cells, we measured the effects of shRNA‐mediated knockdown of CerS1 on the growth of UM‐SCC‐47 cells in response to cisplatin using MTT assay. Here, CERS1 is linked to head and neck squamous cell carcinoma.