This epistatic link is reflected in individual forms of Waardenburg syndrome (WS), an inherited sensorineural deafness condition, in which MITF mutations are implicated in WS type IIA and mutations in EDNRB (the relevant EDN receptor in melanocytic cells) in WS type IV (Saldana‐Caboverde & Kos, 2010). Here, EDNRB is linked to Werner syndrome.