In human DC, exposure to cyclosporine A reduces interferon (IFN)‐α responses to Sendai virus (Tajima et al, 2003), while macrophages from NFAT4 knockout mice display reduced iNOS expression and attenuated bactericidal activity in a sepsis model, consistent with the ability of calcineurin inhibitors to block NFAT4 binding to the iNOS promoter (Ranjan et al, 2014). Here, NFATC3 is linked to Sepsis.