MYH7 and familial dilated cardiomyopathy: By contrast, DCM MYH7 variants decrease Ca2+-sensitivity and reduce motor domain functions (Debold et al., 2007; Moore et al., 2012; Spudich, 2014; Marston, 2011; Spudich et al., 2016), therein accounting for diminished contractile performance, the prototypic feature of DCM.