SRPK1 and hepatocellular carcinoma: To elucidate the molecular mechanisms by which miR-1296 exerts its functional effects on HCC cells, we predicted potential targets by different miRNA target algorithms (TargetScan, miRanda and miRbase) and found conserved putative miR-1296 binding sites at the 3′-UTR of SRPK1 (Fig. 4a).