We have previously shown the pro-survival advantages of Buffy, the sole anti-apoptotic Bcl-2 homologue in Drosophila by its rescue of the α-synuclein-induced phenotypes [29], in the HtrA2 model of PD [30], we extended this study to investigate whether Buffy would rescue the loss of Pdxk-induced phenotypes in Drosophila. The gene discussed is PDXK; the disease is Parkinson disease.