ALK and non-small cell lung carcinoma: To determine the suitable dose with food to improve gastrointestinal tolerability, a randomized trial is currently being conducted to estimate whether lower doses (450 mg or 600 mg) of ceritinib at non-fasted state provides similar steady-state systemic exposure compared to the 750 mg dose taken under fasting conditions in patients with ALK-positive NSCLC (https://www.clinicaltrials.gov/ct2/show/NCT02299505?term%C2%BCLDK378&rank%C2%BC22).