Mice with diet-induced obesity show an increased expression of Choline/Ethanolamine Phosphotransferase 1 (CEPT1), the muscle specific knockout of CEPT1 led to improved insulin sensitivity and levels of CEPT1 expression were inversely correlated with insulin sensitivity in obese human subjects [54]. Here, CEPT1 is linked to obesity due to melanocortin 4 receptor deficiency.