Mice deficient in either Diacylglycerol O-Acyltransferase 1 (DGAT1) or Lecithin-Cholesterol Acyltransferase (LCAT) are resistant to diet induced obesity and insulin resistance [48, 49] and these genes were not essential in any of the tested cell lines which makes them good potential pharmacological targets even if they are both associated to diseases in human (Congenital diarrheal disorder [50] and fish-eye disease [51] respectively). This evidence concerns the gene LCAT and obesity due to melanocortin 4 receptor deficiency.