Participants with cryptococcal meningitis had the lowest median CD4 count (17 cells/μL, IQR: 7–79), the lowest median Karnofsky score (60, IQR: 50–70), the highest proportion of participants with IHDS < =10 (92%), and the highest median scores for depression (CES-D: 23, IQR: 16–30). This evidence concerns the gene CD4 and Cryptococcal meningitis.