Fig 3B shows one representative experiment out of multiple experiments, which overall showed statistically significant differences between control tumor growth versus tumor growth in tTF-NGR treated animals (p < 0.05, Mann-Whitney test).22 CD13 expression in tumor cells of the subcutaneous A549 xenotransplants was demonstrated by immunofluorescence staining (Fig 3C). This evidence concerns the gene RTN4R and neoplasm.