MAP3K11 and breast carcinoma: Metastasis is overwhelmingly the cause of breast cancer-related death, yet the complexity of the metastatic process makes it therapeutically challenging to treat.41 Previous studies in our lab and others have demonstrated that MLK3 is crucial for TNBC metastasis.7, 8 Herein, we utilized the CRISPR/Cas9 approach to deplete MLK3 in the highly aggressive 4T1 mammary cancer model to elucidate the role(s) of MLK3 in discrete steps of metastasis and to identify the key signaling pathways through which MLK3 regulates these events.