TIP30 is an important prognostic predictor for various cancers.19, 48, 49 Upregulated SREBP1 associated with a poor prognosis of HCC patients.50 Remarkably, when the combined effects of TIP30 and SREBP1 were evaluated, the sensitivity for survival analysis of HCC patients was improved. Here, SREBF1 is linked to hepatocellular carcinoma.