Using NCBI GEO databases to analyze the HCC sample array (GEO dataset accession GSE36376),29 we also found the negative correlation of TIP30 and SREBP1 in 240 HCC samples(r=−0.24, P<0.001), showing the same tendency as our results (Supplementary Figure 3). Here, HTATIP2 is linked to hepatocellular carcinoma.