TIP30 exerts its tumor-suppressive role by influencing cell apoptosis, growth, metastasis and angiogenesis.32 Recently, TIP30 has also been confirmed to regulate the metabolic adaptation to glucose limitation of HeLa cells, which contributes to tumor metastasis and aggressiveness.33 For the first time, our study demonstrated that TIP30 is a negative regulator of lipid metabolism in HCC. The gene discussed is HTATIP2; the disease is hepatocellular carcinoma.