HTATIP2 and cancer: Thereafter, mature SREBPs entered nucleus to bind SRE-containing gene promoters to induce transcription.23 Emerging evidence indicates that SREBP1 is a crucial linkage of oncogenic signaling transduction and cancer metabolism.24 To elucidate the molecular mechanisms of the TIP30 deficiency-mediated upregulation of lipogenic enzymes, cellular SREBP1 levels were examined.