KRAS and cancer: The proto-oncogene c-Src (Src) is a non-receptor tyrosine kinase protein, which is associated with multiple aggressive cancers.30, 31 Recent studies have implicated Src tyrosine kinase as an important upstream activator of K-Ras-mediated signaling.32, 33 Integrin ligation is often associated with activation of a dual kinase complex involving focal adhesion kinase and Src.34 In order to examine whether Src-activation is affected by depletion of α6-integrin, we studied the levels of phosphorylated Src in the different cell lines.