Ras/MAPK/ERK pathway is important for growth of many types of cancer cells and it has been implicated in stemness signaling.51 Here we show that K-Ras/MAPK/ERK signaling cascade induces FOSL1 expression that in turn binds to α6-integrin promoter to stimulate transcription of α6-integrin. This evidence concerns the gene FOSL1 and cancer.