As numerous studies link Hh signalling to progression in multiple tumour types, derivatives of cyclopamine (for example, GDC-0449 and IPI926), a naturally occurring plant-derived steroidal alkaloid which targets SMO, are in clinical trials for select patients with BCC and medulloblastoma, and are proving to be efficacious24, 25. The gene discussed is SMO; the disease is medulloblastoma.