Furthermore, increased levels of each of the EMT-TFs, together with high GLI1, also correlated more significantly with worsened prognosis (relapse-free survival and distant metastasis-free survival) in breast cancer patients spanning numerous grades and subtypes, when compared with the EMT-TFs or GLI1 alone (Fig. 7b–d and Supplementary Table 1). This evidence concerns the gene GLI1 and breast carcinoma.