In 2004, Schröder-van der Elst and colleagues evaluated the effects of some flavonoids on cell proliferation and NIS function and expression, using a follicular thyroid carcinoma cell line FTC-133, which does not express NIS and TPO, after transfection of these cells with human sodium iodide symporter cDNA (hNIS). The gene discussed is SLC5A5; the disease is thyroid gland follicular carcinoma.