As a result, we posited that the intra-articular administration of lubricin, which is effective in preventing degeneration in trauma-induced preclinical rodent models [6,9,10,11,12], may also be effective in lubricin-null mice; the orthologous genetic model of CACP syndrome in humans. Here, PRG4 is linked to camptodactyly-arthropathy-coxa vara-pericarditis syndrome.