Similarly, it has been demonstrated that oxaliplatin containing PEGylated liposomes prevent the production of anti-PEG IgM and the consequent ABC response in the so-called SOXL (S1-OXaliplatinum-Liposomes) regimen, a chemotherapy protocol based on the combined use of metronomic S1 and PEGylated oxaliplatin-containing liposomes [132]. The gene discussed is CD40LG; the disease is aneurysmal bone cyst.