According to previous reports [48,63,64,65], melatonin supplementation significantly improves antioxidant status by increasing the activity of antioxidant enzymes (i.e., superoxide dismutase, glutathione peroxidase, catalase, etc.)in T2DM and obesity [48,63,64,65]. Here, CAT is linked to obesity due to melanocortin 4 receptor deficiency.