DVL2 and neural tube defect: Morphogenesis and closure of the neural tube is affected by nutritional, environmental and genetic factors including Wnt/PCP signaling, which is illustrated by genetic association between NTD in humans and mutations in the PCP genes VANGL1, VANGL2, CELSR1, FZD6, and DVL2 (Cai and Shi, 2014; reviewed in De Marco et al., 2014).