Interestingly, evidence is accumulating that DVL1 is functionally associated with Wnt/Ca2+ and CamKII signaling in cardiomyopathy (Malekar et al., 2010; Zhang et al., 2015), in excitory synapses in the rat spinal chord (Ciani et al., 2011) and in convergent extension movements in Xenopus gastrulation (Gentzel et al., 2015), indicating a functional specification of DVL1. This evidence concerns the gene DVL1 and cardiomyopathy.