In the pediatric age, there is also evidence of a “quantitative synergism” between aeroallergen-specific IgE levels (e.g., to house dust mite) and respiratory viral infections in enhancing the odds of acute wheezing and asthma exacerbations, with higher levels of specific IgE conferring the greatest risk (26, 27). The gene discussed is IGHE; the disease is asthma.