TP53 and cancer: Although the structure of ribosomal subunits is very firm and is given by the secondary structure of ribosomal RNAs and the presence of ribosomal proteins (Ban et al., 2000; Schluenzen et al., 2000; Wimberly et al., 2000), ribosome function during translation of mRNAs can be effectively regulated by viral proteins (Diaz et al., 1993, 1996) which reveals the existence of a regulable “ribosomal code.” The regulation of ribosome biogenesis and translation through the p53 pathway and methylation of ribosomal RNA by fibrillarin is leading to cancer specific ribosomes (Marcel et al., 2013).