NR3C1 and breast cancer: Pharmacological targeting of immune signal modulating proteins such as NR3C1 and PPARG were found efficient to decrease the lymphangitic metastasis formation of breast cancer and NSCLC.62 Another relevant example is tamoxifen, an anti-oestrogen targeting the oestrogen receptors, which are the first neighbours of the breast cancer-related HER2 (ERBB2) protein.