IFN-γR is a heterodimer of IFN-γR1 and IFN-γR2 that form the receptor of the Interferon-γ cytokine, which is conventionally associated with antitumor mechanisms during cell-mediated adaptive immune responses.38 Another key cytokine receptor in these immune responses is the IL10 receptor (IL10R), which is highly expressed in the normal colon, but missing in colon cancer. Here, IFNGR2 is linked to colonic neoplasm.