IFNGR1 and colonic neoplasm: IFN-γR a known drug target we found as an influencer protein in four databases and FRAT1, a protein listed as influencer in all five databases but not yet a drug target demonstrate two different types of connectivity pattern in colon cancer (Fig. 3c–d): (1) the influencer protein (IFN-γR) has the same position as the cancer-related protein; (2) the influencer protein (FRAT1) is affecting the cancer-related protein through the first neighbour.