IFNGR2 and malignant colon neoplasm: IFN-γR is a heterodimer of IFN-γR1 and IFN-γR2 that form the receptor of the Interferon-γ cytokine, which is conventionally associated with antitumor mechanisms during cell-mediated adaptive immune responses.38 Another key cytokine receptor in these immune responses is the IL10 receptor (IL10R), which is highly expressed in the normal colon, but missing in colon cancer.