ITGAM and breast carcinoma: In breast cancer, stress resulting from social isolation leads to a transient increase in CD11b+Gr-1+, CD11b+Gr-1−, and F4/80+ macrophage populations (Madden, Szpunar, & Brown, 2013) and may promote breast cancer progression through macrophage M2 polarization (Qin et al., 2015).