To further understand the role of adaptive immunity in the tumor tissue, we investigated the impact of RRS on tumor weight and on immune suppression markers (Foxp3, CCL22), as well as markers for anti-tumor immunity (Granzyme B, CCL5, IFN-γ, CXCL9, CXCL10 and CXCL11). This evidence concerns the gene FOXP3 and neoplasm.