FOXP3 and colorectal carcinoma: Among various FoxP3 and Helios Treg subsets, the proportion of FoxP3−Helios+ Treg subset was relatively high in PBMCs of HD and CRC patients, whereas FoxP3+Helios+ Treg subset proportion was highest in TILs (54%) compared to NILs (26.3%), PBMCs (26.2%) of cancer patients (Figure 3D).