CD274 and neoplasm: On the other hand, many reports indicate that in certain cases radiation therapy creates a more immunosuppressive microenvironment due to the upregulation of PD-L1, a transient potentiation of tumor hypoxia, or an alternative activation of TAMs, indicating that the addition of immunotherapy to the treatment protocol can overcome these obstacles, increase radiosensitivity and may lead to an enhanced systemic effect of radiation therapy.