Although DCs represent the most important APCs to cross-present tumor antigens to effector T cells and to activate antitumor T cell response, these essential capacities are paralyzed by tumor-derived inhibitory factors including IL-10, TGF-β, vascular endothelial growth factor A (VEGF-A), and arginase (71). The gene discussed is TGFB1; the disease is neoplasm.