In many cases, tumor-infiltrating DCs gradually develop an immunosuppressive phenotype characterized by lower expression of co-stimulatory molecules, decreased antigen-presenting activity and upregulation of regulatory molecules and receptors such as PD-1 and TIM-3 within tumor-microenvironment, as the tumor grow from early stages to advanced diseases (71, 72). This evidence concerns the gene PDCD1 and neoplasm.