Studies have shown an association between Treg infiltration into the liver and recurrence of tumor metastases and multicentric cancer after hepatic resection (164), coinfiltration by FOXP3+ Treg and B7-H1+PD-1+ T lymphocytes with high-risk breast cancer (165), density of FOXP3+ lymphocytes with lymph node metastases of pancreatic cancer (166), and expression of FOXP3 and p16INK4a with progression of cervical cancer, more specifically with lymph node metastasis (167). The gene discussed is FOXP3; the disease is neoplasm.