In 2012, Dennis et al. have performed a meta-analysis on the relationship between EPCR gene Ser219Gly variant and common thrombotic disorders risk (Dennis et al., 2012) that found a significant association between the EPCR rs867186 variant and VTE, but their analysis included studies by Medina et al. in 2004 and Yamagishi et al. in 2009 that had non-HWE controls (Medina et al., 2004; Yamagishi et al., 2009). This evidence concerns the gene PROCR and thrombotic disease.