Taken together, YXQN treatment groups had substantially reduced Aβ deposition in the hippocampus and cortical regions in a dose-dependent manner, suggesting that YXQN extract ameliorated cognitive impairment in MWM and Y-maze probably through reducing the Aβ deposition in the hippocampus and cortical areas of APP/PS1 mice. Here, APP is linked to Cognitive impairment.