Compared with vehicle AD mice, YXQN low-, middle-, and high-dose APP/PS1 mice and donepezil APP/PS1 mice showed different degrees of shortened latencies, and YXQN high-dose group most closely approached the latencies of the WT group, and presented significant differences with vehicle group on day 3 and 4 (F = 2.948 and 2.572; p = 0.036 and 0.036). Here, APP is linked to Alzheimer disease.