In the clinical, Cx26 mutations can cause both congenital deafness and late-onset hearing loss (del Castillo and del Castillo, 2011; Chan and Chang, 2014), also implicating that Cx26 deficiency induced hearing loss may have different underlying deafness mechanisms rather than a unique deafness mechanism as assumed by K+-recycling defect hypothesis. This evidence concerns the gene GJB2 and hearing loss disorder.