On the one hand t-PA is used as a drug to lyse thrombi during stroke treatment, on the other hand it is known that t-PA contributes to BBB breakdown via MMP activation or cleavage of membrane receptors of the brain endothelium (Pfefferkorn and Rosenberg, 2003; Adibhatla and Hatcher, 2008). This evidence concerns the gene PLAT and stroke disorder.