We have already shown that global elimination of PAPP‐A gene expression has multiple positive effects, for example, resistance to: atherosclerotic plaque progression (Harrington et al., 2007), thymic involution and immune senescence (Vallejo et al., 2009), development of diabetic nephropathy (Mader et al., 2013), and visceral obesity (Conover et al., 2013b). This evidence concerns the gene PAPPA and diabetic kidney disease.