ANGPTL8 and fatty liver disease: These relationships were further substantiated by the observation of parallel increases of ANGPTL8 levels with the severity of liver steatosis (p = 0.01 by repeated measures ANOVA) (Fig. 3), and by association observed between ANGPTL8 levels and liver steatosis in the group of obese controls (r = 0.53, p < 0.05).