In hepatoma cells, Tseng YH et al. demonstrated that ANGPTL8 is mainly localized in the cytoplasm with a vesicle-like distribution18, possibly implying that hepatocyte lysis linked to steatosis could promote the leakage of ANGPTL8 vesicle in the bloodstream, thus helping to explain our findings. The gene discussed is ANGPTL8; the disease is hepatocellular carcinoma.