Bearing in mind the limitation of our approach, current data confirm that liver steatosis is less severe in PWS than in common obesity37, and substantiates the emerging role of liver steatosis on circulating ANGPTL8 in severe obesity, which is further strengthened by the results of correlation analyses and multivariable regression analyses. Here, ANGPTL8 is linked to obesity due to melanocortin 4 receptor deficiency.